Endocrine Abstracts

Androgen receptor (AR, NR3C4) is a 110-kDa ligand-activated transcriptional factor that belongs to the steroid hormone receptor superfamily. It has broad developmental effects and its mutations may have a great impact on pubertal development, genesis of prostatic hyperplasia, and even prostate cancer. Commonly known endogenous ligands of AR are testosterone and 5α-dihydrotestosterone (DHT). In the last years, several drugs and environmental pollutants were identified to a...